Common variable immunodeficiency (CVID) is an immunodeficiency problem that causes a child to have a low level of antibodies and a decreased responsiveness to some vaccines. This makes it hard for the child’s body to fight infections. The child then becomes sick with infections that keep coming back. Most people with CVID become sick and are diagnosed as adults. But in some cases, the disease may become obvious after a child is 2 years old, during childhood or puberty. The symptoms of the disease are very different for each child affected. This is why it is called a variable group of disorders.
Experts don't know what causes CVID. The disorder causes a decrease in the number of immunoglobulins (antibodies) in the child who has it. Immunoglobulins are made by the body. They are needed to fight infections. In some cases, more than one person in a family may be affected.
The only known risk factor for CVID is a family history of the problem.
Each child may have slightly different symptoms. Symptoms may include:
A diagnosis of CVID is often made based on a complete health history and physical exam. In addition, multiple blood tests may be ordered to help confirm the diagnosis. Testing for low serum IgG concentrations is key to diagnosing this health problem.
Treatment will depend on your child’s symptoms, age, and general health. It will also depend on how severe the condition is.
Treatment may include:
Infections, and the results of those infections, are the greatest complication of CVID. With correct treatment, the number and severity of infections should be reduced. Adults with CVID have an increased risk of developing cancer.
CVID is a lifelong health problem that can lead to a reduced ability to fight infections. The current therapies can reduce the number and severity of infections. It's important to help your child stay out of situations that have a greater risk for infection. Have them wash their hands often with soap and water. Include your healthcare provider in the discussion about school attendance and after-school activities. Most children are able to take part in all activities. But they should use caution. They should not do activities when the risk for infection is higher. It's also important that you work closely with a specialist who is familiar with CVID and the newest treatments.
Call the healthcare provider if your child’s symptoms get worse or if your child has new symptoms.
CVID is an immunodeficiency problem. It causes a child to have a low level of antibodies and a decreased responsiveness to some vaccines. This makes it hard for the child's body to fight diseases.
Children with CVID have infections that keep coming back. These can affect the eyes, skin, ears, sinuses, lungs, joints, and GI tract.
The joints and skin are also often affected by inflammation and rashes not caused by an infection.
Treatment includes immunoglobulin therapy, medicines, routine blood tests, and postural drainage of the lungs.
It is also important to help your child stay out of situations that have a greater risk for infection and wash their hands often with soap and water.
Tips to help you get the most from a visit to your child’s healthcare provider: